Samantha Mathis is an American actress, best known for Buried, American Psycho, Broken Arrow, and Little Women. Other film credits include Camilla Dickinson, Believe in Me, Local Color, The Punisher, Sweet Jane, The American President, Jack & Sarah, The Music of Chance, and Pump Up the Volume.

Television credits include as Justine Feraldo on FX’s The Strain, Dr. Alice Calvert on CBS’ Under the Dome, Melinda Prescott on ABC’s Grey's Anatomy, and Gwenwyfar in the TNT miniseries The Mists of Avalon.

Theatre credits include her Broadway debut as Hester Falk in The Man Who Had All the Luck (American Airlines Theatre) and Clara Brandt in 33 Variations (Eugene O'Neill Theatre); Off-Broadway, in Love, Loss and What I Wore (Westside Theatre); and regionally, as Yelena Andreyevna in Uncle Vanya (Intiman Theatre) and Lisa Morrison in Collected Stories (Geffen Playhouse).